The Alpha One Foundation is pleased to announce participation in the MRCG-HRB Joint Funding Scheme 2017, a collaboration between the Health Research Board (HRB) and the Medical Research Charities Group (MRCG). 

MRCG HRB 10 years

The Alpha One Foundation is committed to encouraging research into alpha-1 antitrypsin deficiency. As we gain more knowledge and understanding about Alpha-1 through research, we come closer to one day finding a cure. For this MRCG-HRB co-funding scheme, we are inviting original research proposals that will lead to a better understanding of one of the most common genetic conditions in Ireland.

Priority will be given to applications that incorporate meaningful public and patient involvement (PPI) in the proposed research projects. 

Application Process
Funding applications are invited for translational research projects focused solely on Alpha-1. The grants available are up to a total of €300k for between 12 to 36 month periods with projects anticipated to begin September 2018. 

Full details of the scheme can be found at: It is strongly recommended that prospective applicants read the full MRCG-HRB Application Form and HRB Instructions to Applicants provided on the MRCG website before deciding to proceed. 

Key Dates

  • Alpha One Foundation call for funding: 6th November, 2017 - 30th November, 2017
  • Deadline for submission of full applications: 5pm on Friday, 26th January 2018
  • Alpha One Foundation Peer Review phase: November - January 2017
  • Alpha One Foundation submits applications to HRB: 12th February 2018
  • Right-to Reply Phase: Early - mid February 2018
  • Charity Selection Committee: Late Feb - March 2018
  • HRB Application Deadline: 9th April 2018
  • Joint Funding Committee Meeting: June 2018
  • Applicant Notification: July 2018
  • Research Project Start Date: From September 2018

For more information please contact This email address is being protected from spambots. You need JavaScript enabled to view it. or phone 01-8093871. 

What is Alpha-1 Antitrypsin?
Alpha-1 antitrypsin is a vital protein produced by the liver to protect the lungs. It provides protection from the harmful effects of infections and inhaled irritants, particularly tobacco smoke. It can be easily measured by a simple blood test. 
What is Alpha-1 Antitrypsin Deficiency?
Alpha-1 antitrypsin deficiency (Alpha-1) is a genetic condition which, after cystic fibrosis, is the commonest genetic disorder in Ireland. It severely affects more than 15,000 people, with another 250,000 carriers also at risk of lung and liver disease on the island of Ireland. It is a proven genetic risk factor for chronic obstructive pulmonary disease (COPD).
How Do I Get Tested?
The Alpha One Foundation provides free testing for Alpha-1 as part of a national screening programme which is funded by the HSE. For more details ring 01-8093871 or email