Alpha-1 antitrypsin (AAT) level and/or phenotype. In some cases, the AAT level may have been measured previously. This information should be provided on the form to accompany the blood sample.
Who Should be Tested?
The World Health Organisation (WHO), American Thoracic Society (ATS), and European Respiratory Society (ERS) together recommend the following cohorts for screening;
• COPD, regardless of age or smoking history
• Severe, non-responsive/refractory asthma
• Cryptogenic liver disease
• All first-degree relatives of known Alphas
• Individuals with reduced serum levels of AAT
We require 1 serum or plasma sample – the minimum volume required is 3.0 mls. The blood sample should be carefully labelled with name, DOB, etc. and sent to:
Alpha One Foundation, RCSI Smurfit Building,Beaumont Hospital, Dublin 9.
What Happens Next
The blood sample can be sent directly to the Alpha One Foundation where the test is performed. Results of the test are then returned to the requesting doctor in approximately 2 weeks.